Ochoa, E.L.M. and Lasalde-Dominicci, J. A., (2007) Cognitive deficits in schizophrenia: focus on neuronal nicotinic acetylcholine receptors. Cell Mol Neurobiol. (In press)

Valerie Wojna, Lizbeth Robles, Richard L. Skolasky, Raul Mayo,4, Ola Selnes, Tania de la Torre, Elizabeth Maldonado1, Avindra Nath, Loyda M. Meléndez and Jose Lasalde-Dominicci, (2007) Cigarette Smoking and Cognitive Function in HIV-seropositive Women, Journal of NeuroVirology. (In press)

José David Otero-Cruz, David Abner Torres-Núñez, Carlos A. Báez-Pagán, José Antonio Lasalde-Dominicci (2007) Fourier Transform Coupled to Tryptophan-Scanning Mutagenesis: Lessons from its Application to the Prediction of Secondary Structure in the Acetylcholine Receptor Lipid-Exposed Transmembrane Domains, Biophysical Journal- Biophysical Letters (Submitted)

Gisila R. Guzmán, Alejandro Ortiz-Acevedo, Ariamsi Ricardo, Legier V. Rojas and José A. Lasalde-Dominicci, (2007) The polarity of lipid-exposed residues contributes to the functional differences between Torpedo and muscle type nicotinic receptors, J. of Membrane Biology (In press) 

Carlos A. Báez-Pagán, Yaiza Martínez-Ortiz, José D. Otero-Cruz, Iris K. Salgado-Villanueva, Guermarie Velázquez, Alejandro Ortiz-Acevedo, Orestes Quesada, Walter I. Silva & José A. Lasalde-Dominicci, (2007) Regulation of the acetylcholine receptor functional pool via caveolin-1-positive domains, JBC (Submitted) 

José David Otero-Cruz, Carlos Alberto Báez-Pagán, Iván Manuel Caraballo-González and José Antonio Lasalde-Dominicci, (2007) Tryptophan Scanning Mutagenesis in the aM3 Transmembrane Domain of the Muscle-Type Acetylcholine Receptor: a Spring Model Revealed, JBC Vol. 282, No. 12, pp. 9162-9167. 

Madeline Nieves-Cintron, Daniel Caballero-Rivera, Manuel F. Navedo, and Jose A. Lasalde-Dominicci (2006) Contribution of Valine 70 of TMD2 to Gating of Neuronal a3 Receptor Subtypes, Journal of Neuroscience Research 84:1778–1788 

Roberto Zayas, Jose Lasalde-Dominicci, AND Christopher M. Gomez (2006) Macroscopic Properties of Spontaneous Mutations in Slow-Channel Syndrome: Correlation by Domain and Disease Severity, SYNAPSE 60:441–449  

Manuel F. Navedo, Jose´ A. Lasalde-Dominicci, Carlos A. Baez-Pagan, Luzed Dıaz-Perez, Legier V. Rojas, Ricardo A. Maselli, Julie Staub, Kelly Schott, Roberto Zayas, and Christopher M. Gomeze, (2006) Novel B subunit mutation causes a slow-channel syndrome by 3 enhancing activation and decreasing the rate of agonist dissociation Mol. Cell. Neurosci. 

Gretchen Y. Lopez-Hernandez, Javier Sanchez-Padilla, Alejandro Ortiz-Acevedo, Jose´ Lizardi-Ortiz, Janice Salas-Vincenty, Legier V. Rojas, and Jose´ A. Lasalde-Dominicci, (2004) Nicotine-induced Up-regulation and Desensitization of a4b2 Neuronal Nicotinic Receptors Depend on Subunit Ratio. JBC Vol. 279, No. 36, pp. 38007–38015.  

John Santiago, Gisila R. Guzman, Karla Torruellas, Legier V. Rojas, and Jose´ A. Lasalde-Dominicci (2004) Tryptophan Scanning Mutagenesis in the TM3 Domain of the Torpedo californica Acetylcholine Receptor Beta Subunit Reveals an a-Helical Structure. Biochemistry 43, 10064-10070.

Alejandro Ortiz-Acevedo, Mariel Melendez, Aloysha M. Asseo, Nilza Biaggi, Legier V. Rojas, and Jose´ A. Lasalde-Dominicci (2004) Tryptophan Scanning Mutagenesis of the gM4 Transmembrane Domain of the Acetylcholine Receptor from Torpedo californica. JBC Vol. 279, No. 40, pp. 42250–42257.

Manuel Navedo, Madeline Nieves, Legier Rojas, and Jose A. Lasalde-Dominicci (2004) Tryptophan Substitutions Reveal the Role of Nicotinic Acetylcholine Receptor a-TM3 Domain in Channel Gating: Differences between Torpedo and Muscle-Type AChR Biochemistry  43, 78-84

Guzman, G., Santiago, J., Rojas, L., and Lasalde-Dominicci, J. A., (2003). Functional effects of tryptophan substitutions in the alpha M3 transmembrane domain of the Torpedo californica nicotinic acetylcholine receptor; Structural and Functional interpretation, Biochemistry Vol 42 num42 October 28, p12243-12250.

Rojas, L. V., Bonilla, L., Baez, S. and Lasalde-Dominicci, J. A. (2003) 3,5,3’triiodethyronine controls miniature end plate currents frequency of pre- and pro-metamorphic tadpoles: Implication in the apoptotic mechanism. Journal of Neuroscience Research Vol 71: Issue 5, 670-678.

Gisila R. Guzmán, Alejandro Ortiz-Acevedo, John Santiago Legier V. Rojas and José A. Lasalde-Dominicci (2002) Regulation of Acetylcholine Receptor function by Cholesterol, (invited Book Chapter in Recent Research Developments in Membrane Biology, (2002): ISBN: 81-7736-181-3, p127-146.

A. Cruz-Martın, J.L. Mercado1, L.V. Rojas, M.G. McNamee, J.A. Lasalde-Dominicci (2001) Tryptophan Substitutions at Lipid-exposed Positions of the Gamma M3 Transmembrane Domain Increase the Macroscopic Ionic Current Response of the Torpedo californica Nicotinic Acetylcholine Receptor J. Membrane Biol. 183, 61–70.

John Santiago, Gisila R. Guzman, Legier V. Rojas, Ricardo Marti, Guillermo A. Asmar-Rovira, Luis F. Santana, Mark McNamee, and Jose´ A. Lasalde-Dominicci (2001) Probing the Effects of Membrane Cholesterol in the Torpedo californica Acetylcholine Receptor and the Novel Lipid-exposed Mutation  C418W in Xenopus Oocytes  JBC Vol. 276, No. 49, pp. 46523–46532.

Christopher M. Gomez, MD, Ricardo A. Maselli, Bhupinder P. S. Vohra, Manuel Navedo,  Joel R. Stiles, MD, Pierre Charnet, Kelly Schott, Legier Rojas, John Keesey, Anthony Verity, Robert W. Wollmann, and Jose Lasalde-Dominicci, (2002) Novel Delta Subunit Mutation in Slow-Channel Syndrome Causes Severe Weakness by Novel Mechanisms. Ann Neurol 51:102–112 

Shiori Tamamizu, Gisila R. Guzman, John Santiago, Legier V. Rojas, Mark G. McNamee, and Jose´ A. Lasalde-Dominicci (2000) Functional Effects of Periodic Tryptophan Substitutions in the aM4 Transmembrane Domain of the Torpedo californica Nicotinic Acetylcholine Receptor.  Biochemistry 2000, 39, 4666-4673.

Tamamizu, S., Guzman, G., Santiago, J., Rojas, L.V., McNamee, M. G. and Lasalde-Dominicci, J. A., Functional effects of periodic tryptophan substitutions in the alpha M4 transmembrane domain of the Torpedo californica nicotinic acetylcholine receptor.  Biochemistry Vol 39, Number 016, 4666-4673 (2000).

Tamamizu, S., Lee Y-H., M.G. McNamee and Lasalde-Dominicci, J.A.,  Mutations at the lipid protein interface of the mouse Acetylcholine receptor alter channel gating. Journal of Membrane Biology Vol 170 July 157-164 (1999).

Ortíz, S., Lasalde, J. A., Pappone, P., and McNamee, M.  A kinetic analysis of the C418W mutant of the Torpedo californica  acetylcholine receptor. Journal of Membrane Biology  Vol 158 17-30. (1997).

Gomez, C.M., Masselli, R., Gammack, B.S., Lasalde, J.A., Tamamizu, S., Comblath, D.R., Lehar, M., McNamee, M., and Robert L. Wolimann. Slow-Channel Transgenic mice: a model of postsynaptic organellar degeneration at the neuromuscular junction. Journal of Neuroscience  June 1, 17 (11):4170-4179 (1997).

Butler, D.H., Lasalde, J.A., Butler, J., Zimmerman, G., and McNamee, M.G.  Mouse-Torpedo chimeric a subunits used to probe open time determinats on the nAChR primary sequence. Cellular and Molecular Neurobiology  Vol. 17 No.1 13-33 (1997).

Lasalde, J.A., Tamamizu, S., Butler, D.H., Vibat, C.R.T., and McNamee, M.G. Tryptophan substitutions at the lipid exposed transmembrane segment M4 of the Torpedo californica  acetylcholine receptor are critical for channel gating. Biochemistry  Vol 35, Num 45 14139-14138 (1996).

Tamamizu, S., Butler, D., Lasalde, J. A., and McNamee, M.G.  Monoclonal antibodies probe structural transitions of the nicotinic acetylcholine receptor.  Biochemistry  Vol 35, Num 36 11773-11781 (1996).

Gomez, C.M., Tamamizu, S., Lasalde, J.A. et al., nd Knucl, R.W. In vivo and in vitro properties of  an Acetylcholine receptor mutation in the slow-channel myastenic syndrome. Neurology : 46 (2) 310-11 (1996).

Gomez, C.M., Masselli, R., Gammack, B.S., Lasalde, J. A., Tamamizu, S., Comblath, D.R., Lehar, M., McNamee, M., and Knucl, R.W.  A b subunit mutation in the Acetylcholine receptor channel gate causes a severe slow-channel myasthenic syndrome.  Annals of Neurology : 39:712-721 (1996).

Vibat, C.R.T., Lasalde, J.A., McNamee, M.G., and Ochoa, E.L.M.  Differential desensitization properties of rat neuronal nicotinic acetylcholine receptor subunit combinations expressed in Xenopus laevis oocytes.  Cellular and Molecular Neurobiology 15:411-425, (1995).

Lasalde, J.A., Colom, A., Resto, E., and Zuazága C.  Heterogeneous distribution of acetylcholine channel induced by cholesterol enrichment.  Biophysical & Biochemical Acta 1235:427-438, (1995).

Lee, Y., Li, L., Lasalde, J. A., Rojas, L., Pappone, P., Ortíz, S., and McNamee, M.  Mutations in the M4 domain of the Torpedo californica AChR: dramatically alter ion channel function.  Biophysical Journal 66:646-653, (1994).

Escalona de Motta, G., Mercado, J.A., Tosteson, T.R., González, I. and Lasalde, J.A.  Modulation of acetylcholine channel by a polar component isolated from toxic Ostreopsis lenticularis extracts.  Bull. Soc. Path. Ex. 85: 489-493, (1993).

Lasalde, J.A. (Book Chapter) A correlation between patch clamp and fluorescence anisotropy experiments to study alterations on the acetylcholine channel induced by cholesterol enrichment in chick myocytes. In: Membrane proteins: structures, interactions and models, Kluwer Academic Publishers, A. Pullman et al. (eds.) 199-212, (1992).

Rojas, L., Lasalde, J.A. and Zuazága, C.  El receptor nicotínico para la acetilcolina, importancia de enlaces disulfuro en la actividad unitaria.  En: Investigaciones recientes sobre mecanismos de transporte de iones en membranas biológicas, A. Bendimyl Proeblo, (ed.) Monte Avila, 33-40, (1992).

Eterovic, V.A., Hann, R.M., Ferchmin, P.A., Escalona de Motta, G., Del Castillo, J., Prieto, J.A. and Lasalde, J.A.  Positive modulators of acetylcholine receptors: differences between skeletal muscle and electric organ.  In: Molecular Biology of Neuroreceptors and Ion Channels, NATO-ASI Series, A. Maelicke, (ed.) Vol. H 32: 565-584, (1989).

Eterovic, V.A., Escalona de Motta, G., Hann, R.M., Lasalde, J.A., Prieto, J.A., and Ferchmin, P.A. Positive modulators of muscle acetylcholine receptor.  J. Receptor Res. 9:107-125, (1989).