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[Under Construction]
 
Ongoing Research
  1. "Cholesterol and lipid protein interactions affect acetylcholine channel function" Principal Investigator: José A. Lasalde Dominicci, Ph. D. Agency National Institute of General Medical Sciences (NIGMS)Type: R01 (2RO1GM5637), Period: 5/31-2002-4/31-2006.  The long-range goal of this research proposal is to define the functional role of lipid-protein interactions in the conformational transitions of the Nicotinic Acetylcholine receptor (AChR).
     
  2. "Structure Funtion studies on nicotinic receptors"- Program Director: Rafael Arce, Ph.D., Co-PI: José A. Lasalde Dominicci, Ph. D. Type: Institutional Minority Training Grant SCORE program NIGMS (NIH MBRS S06 GM08102): Period 7/1/2004-8/31/2008.  The goal of this project is to define the allosteric sites of the M4 trasmembrane segment of the Torpedo AChR.  This project focus on the interaction of general anesthetics with lipid exposed mutations on also the analisys of lipid exposed allosteric position in the M4 domain.
     
  3. "Acetylcholine receptor genes in slow channel syndrome" - Principal Investigator: Christopher Gómez, Ph. D., Co-PI: José A. Lasalde Dominicci, Ph. D.  Type: R01 (2RO1NS33202-05) period: 9/1/2003-8/31/2007.  The goal of this project is to understand the pathophysiology and molecular mechanisms involved in the impairment of neuromuscular transmission in the slow channel congenital myasthenic syndrome.

Completed Research
  1. "Screening for Torpedo Acetycholine receptor crystal from electric organ".  Supplemental Grant to 2R01GM56371-06 Principal investigator: José A. Lasalde Dominicci, Ph. D. Type: 3S03GM008102-32S2 (Years 2003-05) Period: July 1, 2003 to May 31, 2005.
     
  2. "Membrane cholesterol and lipid-protein Interactions alter Acetycholine receptor function" Type: NIGMS RO1GM 56371-05, Principal Investigator: J. A. Lasalde Dominicci Period: 8/97-12/01/2002.
     
  3. "Structure and Function of nicotinic receptors".  Type NIGMS NIH MBRS S06 GM8102; 2004.  Principal investigator: José A. Lasalde Dominicci, Period: 6/2000-8/2004.  The goal of this project was to define the allosteric sites on the M4 trasmembrane segment of the Torpedo AChR.
     
  4. "Acetylcholine receptor genes in slow channel syndrome" Consortium Agreement Type: Natural Institute of Health-(2RO1-N33202) CO-P.I (Principal Investigator - Christopher Gómez, J. A. Lasalde Dominicci Co Principal Investigator: 10% effort) Period: January 1, 1999 to July 31, 2004.
     
  5. 1/99-7/2001 National Science Foundation-EPSCoR  P.I. “Confocal Imaging Facility”      ($200,000)
     
  6. 5/99-7/2001 National Institute of Health NCRR.  "Instrumentration for confocal microscope" ($263,000) (Principal Investigator)
     
  7. 8/200-7/2001 National Science Foundation-EPSCoR Instrumentation for Multiphoton confocal imaging ($210,000). 
 

 

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